I get migraines and I occasionally seem to get some relief by eating something that is a little too hot for me so I get a lasting and slightly uncomfortable mouth burn. Hard to do when the migraine leaves you nauseated. I also remember reading about an experiment where they had people with headaches (not sure if it was migraines or cluster headaches) and they took a qtip dipped in capsiacin and dabbed some deep inside the nostril on the side that was hurting. My memory is that it helped somewhat but since nobody is marketing it, maybe not. Try checking Medline. I have a problem with my eye where it gets scratched repeatedly and is very painful and I've discovered, by accident, that a little (not a lot) of chile- eye actually relieves the pain for a little while. Probably at least partly by stimulating lots of tears. Erica naughyde@aol.com