Oatmeal Jack asked: "George, could you remember which issue of Nature it was that had capsiacin and substance P in it?" and I have to say I do not remember exactly. It was late Summer or early Fall this year when I read (or tried to read) the article. My guess would be that it came out some time between April and July. Should be fairly easy to find in a library stack. My source of knowledge about substance P could have been one of the books, like Jean Andrews _Peppers_. George