Martha Hepworth (Martha Hepworth <martha@cheme.caltech.edu> ) made a very helpful posting to help answer the question when the article in Nature appeared that talked about how the nerve responses worked when stimulated by capsaicin. I thought the articles were in 1999. The one article may have been "1) A capsaicin-receptor homologue with a high threshold for noxious heat" Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D NATURE 398: (6726) 436-441 APR 1 1999 I did a search a couple years back, though, and this one actually looks more promising: Nature 1997 Oct 23;389(6653): 816-24 The capsaicin receptor: a heat-activated ion channel in the pain pathway. Caterina, MJ; Schumacher, MA; Tominaga, M; Rosen, TA; Levine, JD; and Julius, D UCSF Because the following commentary appeared in the same issue. Nature 1997 Oct 23;389(6653): 783-4 Clapham, DE Some like it hot: spicing up ion channels. If this is true, time has flown. I hope it is due to chile-induced euphoria and not due to advancing age. George